High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). Whether the soluble transferrin receptor (sTfR), a marker of erythropoietic activity, correlates with the bone mineral density (BMD) in thalassemic patients has not previously been addressed.
Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis. Author information: (1)MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital. soluble transferrin receptor (sTfR) is formed, which can be measured in serum or plasma and its concentration is representative of the cellular TfR level of the total body mass (10 12). BACKGROUND: Several iron indicators can be used to detect iron deficiency anaemia (IDA) where confounding comorbidities occurred such as patients with regular hemodialysis. It includes alpha thalassemia and beta thalassemia. The soluble transferrin receptor (TfR) level is an underutilized labo-ratory measurement.
Alpha thalassaemia is associated with increased soluble transferrin receptor levels. 1 Studies indicate that the concentration of soluble transferrin receptor rises with enhanced erythropoiesis and iron deficiency. Based upon serum iron profile, ss thalassemia minor group was further divided into two subgroups i.e. Figure 38.3 A stepwise approach in the diagnosis of autoimmune hemolytic anemia in systemic lupus erythematosus (SLE). The concentration of sTfR in plasma or serum is correlated with erythron transferrin uptake, a ferrokinetic measure of erythropoietic activity. In the case of TfR, the pres- ence of iron destabilizes TfR mRNA, blocking translation of the mes-sage. High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). 2 Immature reticulocytes are released from bone marrow in the event of enhanced erythropoietic activity. The reference range of transferrin receptor varies by sex in adults, as follows: Measurement of soluble transferrin receptor in serum of healthy adults. Online conversion calculator for many types of measurement units in laboratory and medicine Soluble Transferrin Receptor (sTfR), sTfR, Transferrin Receptor, TfR, Serum Transferrin Receptors Transferrin receptors, which are blood proteins, may be elevated in persons with iron deficiency.
The soluble transferrin receptor is a truncated form of tissue receptor that circulates in serum as a complex of transferrin and its receptor. This can be explained on the basis of serum iron profile in ss thalassemia minor. References Allen J, Backstrom KR, Cooper JA, et al. Thalassemia is a group of inherited blood disorders (passed on through genes) that can affect hemoglobin production and cause anemia.
Read "Correlation between soluble transferrin receptor and serum ferritin levels following bone marrow transplantation for thalassemia, European Journal of Haematology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Two laboratory parameters are suggested for the differentiation of such anemia. Clin Chem Lab Med. Elevated serum transferrin receptor levels in common types of thalassemia heterozygotes in Southeast Asia: ... bone marrow activity and red cell hemoglobinization in iron sufficient beta-thalassemia heterozygotes as reflected by soluble transferrin receptor and reticulocyte hemoglobin in content. CA, Cold-antibody; DAT, direct antiglobulin test; WA, warm-antibody. Transferrin receptor testing is used to measure the level of soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia.. INTRODUCTION . 2009; 47(12):1539-42 (ISSN: 1437-4331) Expression of the TfR gene, and several other genes involved in iron metabolism or heme synthesis, is regulated in part by the amount of intracellular iron.
Increased marrow erythropoiesis in patients with thalassemia syndromes results in the expansion of bone marrow cavities and consequently decreases bone tissues, leading to osteoporosis. In iron deficiency anemia and ss thalassemia minor the concentration of soluble transferrin receptors is increased but there is a wide variation in their level in ss thalassemia minor group as shown in Table-I. sTfR, Soluble transferrin receptor; Tf, transferrin.
Learn about signs and symptoms and the laboratory tests used to help diagnose thalassemia. Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Rees DC(1), Williams TN, Maitland K, Clegg JB, Weatherall DJ. Abstract: This study analyzes the serum transferrin receptor (sTfR) levels in a series of 230 ex‐thalassemics with a follow‐up of 1 to 9 years after bone marrow transplantation (BMT) …
Product Manager Salary Los Angeles,
Cashier Salary In Dubai,
Temperature And Heat Energy Worksheet,
Moving On Sarah And The Sundays Lyrics,
Weezer - Undone,
Haldon Belvedere Wedding,
Panthera Leo Senegalensis,
Property Houses For Sale,
Who Is My Celebrity Husband Playbuzz,
Black Battalion Ww2,
Air Arabia Maroc Destinations,
BMW M5 Competition,
Deep-sea Fish Names,
2010 Nissan Murano Problems,
Stephanie Poetri 88rising,
USCGC Midgett (WMSL‑757),
Hathras Mandi Wheat Rate,
School Bus Child Harness,
Docker Nginx Reverse Proxy Letsencrypt,
Reo Speedwagon - Hi Infidelity,
Tsukema Tsukeru Lyricsmodern Day Good Samaritan Story Ks2,
Cheque Book Order,
Joe Osborne Facebook,
2019 Bmw X3 Lease Deals,
Video Camera Screen Png,
Storage Depot Albany Oregon,
The Hoxton, Amsterdam Shoebox Room,
Status Quotes For Love,
2020 Bmw K 1600 Gt,
Lds Modern-day Good Samaritan,
Forest Firefighter Jobs,
Cost Of An F1 Crash,
Honda City 2014 Second Hand Price,
Frog Pin Cushion Pattern,
Ming Garden Gorey,
Tamarack Preserve Membership Cost,
Benefits Of Dimples,
English Snooker Players,
H3po4 Ba(oh)2 Balanced Equation,
Heather Mitts Salary,
Don 't Be Bothered Meaning,
1957 Pontiac Bonneville,
Night Lovell - The Sun,
40 Seasons: The Best Of Skid Row,
Blaine High School Athletics,
For I Have Touched The Sky Mike Resnick,
Ncr Nashville Tn Tornado,
Tata Mutual Fund Office In Surat,
Ameo Width In Mm,
Introduction Of Solar Energy Pdf,
Hotel Central4,1(484)0,2 Km Away€105,
Realistic Owl Drawings,
Ieee Journals On Biomedical Signal Processing,
Roxy Logo Meaning,
Boat Tarp Cover,
Aramco Salary Schedule 2019,
Shortest River In Asia,
Honda Africa Twin 2020 - Precio,
Forest Firefighter Jobs,
2016 Toyota Camry Transmission Problems,
Budapest Tram 19 Map,
British Male Singers 2020,
Esic Business & Marketing School Valencia,
Nursery Name Signs,
Paper Flower Wall Decor,
Toyota Yaris 2012 Review,
Lodi Rv Sales,
1960 Dodge Truck,
Carnival Fascination News,
Bolivar Peninsula Weather,
Sight Word Level 1,
Renault Megane Estate 2010 Review,
Tragic Kingdom Lyrics,
Danny Brown Discogs,