These results implicated the nucleus as the prime candidate for the location of the signalling pathway at the cellular level that is involved in mediating the effect of T3 on the energy metabolism. Thyroid hormones enhance mitochondrial function in human epidermis. Vidali S, et al. of thyroid hormone upon mitochondrial respiration probably results from mechanisms elicited at the nuclear level, including changes in phospholipid turnover and stimulation of uncoupling protein expression, leading to an increased inner membrane proton leak.
1. Keywords: mitochondria, lipid metabolism, uncoupling, thyroid hormones, diiodothyronines. investigated the regulation of genes involved in mitochondrial pathways by THR. THYROID HORMONE ACTION ON MIrOCHONDRIA. Other thyroid hormones along the hypothalamus – pituitary – thyroid axis (HPT) and the other iodothyronines within the thyroid hormone metabolic pathway influence mitochondrial functioning. Thyroid hormone action in mitochondria. Thyroid hormone improves mitochondrial function and dynamics in lung epithelium to reduce pulmonary fibrosis in mice. Thyroid hormone, mitochondria, nuclear-mitochondrial crosstalk, coactivator, gene regulation, signal pathway. We review the effects of thyroid hormones on mitochondrial energetics and principally oxidative phosphorylation. To obtain equivalent amounts of liver homogenate, two hypothyroid animals were used or one normal, because of the differences in organ size. J Mol Endocrinol. However, mechanisms are not well understood. Thyroid hormone is important for the health of the mitochondria. J Invest Dermatol 2016; 136: 2003-12. The final suspension of mitochondria, in 0.25 M sucrose, was adjusted to contain 15 mg of protein per ml after … Genomic and nongenomic mechanisms have been studied. Thyroid hormone status has a profound impact on mitochondria, the organelles responsible for the majority of cellular adenosine triphosphate (ATP) production. Wrutniak-Cabello C(1), Casas F, Cabello G. Author information: (1)UMR Différenciation Cellulaire et Croissance (INRA, Université Montpellier II, ENSAM), Unité d'Endocrinologie Cellulaire, INRA, 2 Place Viala, 34060 Montpellier Cedex 1, France.

Thyroid hormone status has a profound impact on mitochondria, the organelles responsible for the majority of cellular adenosine triphosphate (ATP) production. Mitochondrial processes such as fission, mitophagy, and biogenesis are regulated by thyroid hormone receptor (THR) and ERRα, both of which are nuclear receptors that alter gene expression when bound to ligand. IV 225 Mitochondria were prepared from the livers of decapitated rats, in 0.25 M sucrose [7]. The demonstration that TRα1 mRNA encodes not only a nuclear thyroid hormone receptor but also two proteins imported into mitochondria with molecular masses of 43 and 28 kDa has provided new clues to understand the pleiotropic influence of iodinated hormones.

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